1889–1894
1889–1894: Quinta y última pandemia de gripe previa a la de 1918. (Volver a Cronología. Personas. Fuentes.)
Then, in 1889, the most explosive and widespread influenza pandemic up to that time appeared suddenly and returned with uncharacteristic perseverance for several years thereafter, causing as many as five successive annual mortality peaks between 1889 and 1894 [4]. However, the 1889 pandemic (now thought to have been caused by an influenza A virus with an H3 subtype haemagglutinin [HA], as determined by archaeserology [5] and supported by recent archaevirology; see below) also occurred in an era ready to study it scientifically. By that time virtually all developed nations had vital statistics systems in place, and thus the levels and pattern of mortality could be documented. More importantly, biomedical research had just entered the microbiological era [6]. By 1889, in the middle of an age of great scientific excitement and progress, researchers were ready to apply their experiences to discovering the cause of an important disease, influenza, for which there had been no clinical material available for nearly 35 years.
(Cronología. Personas. Fuentes.)
